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Biologists discover carotenoid transfer between two proteins

Specialists from the biological faculty of Moscow State University have studied how the photoactive orange carotenoid protein (OCP) exchanges carotenoid with proteins of similar structure. The...

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Sharpest image of Alzheimer's fibrils shows previously unknown details

A team of researchers from Germany and the Netherlands has determined the structure of an amyloid fibril with previously unachieved resolution. The fibrils of the body's own amyloid beta (Aβ) protein...

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A new method provides better insights into real-world network evolution

Nature and society are full of so-called real-world complex systems, such as protein interactions. Theoretical models, called complex networks, describe them and consist of nodes representing any basic...

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New infrared imaging technique reveals molecular orientation of proteins in...

A large international collaboration has used a specialised technique on the infrared microspectroscopy (IRM) beamline at the Australian Synchrotron to determine the structure of proteins in individual...

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Llama-derived nanobodies as a new tool in solving crystal structure

Aarhus University scientists have developed miniature antibodies (nanobodies) that can be labelled on certain amino acids. This provides a direct route for solving new X-ray crystal structures of...

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Large, crystalline lipid scaffolds bring new possibilities to protein, drug...

Proteins and drugs are often attached to lipids to promote crystallization or ensure delivery to targeted tissues within the body, but only the smallest proteins and molecules fit within these fat...

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DNA nanostructures get camouflaged by proteins

Researchers from Aalto University and Helsinki University have reported a strategy that significantly increases the stability of DNA nanostructures against DNA digesting enzymes, enhances delivery...

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New protein study broadens knowledge of molecular basis for disease

Determining how proteins function on a molecular level is crucial to understanding the underlying basis for disease. Now scientists at the University of Notre Dame are one step closer to unraveling the...

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Key to expanding genetic code described

Yale scientists have described the atomic structure of a protein that is the key tool in efforts by synthetic biologists to expand the genetic code.

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Tiny protein coiled coils that self-assemble into cages

(Phys.org)—A large team of researchers with members from Slovenia, the U.K, Serbia, France and Spain has developed a technique that causes proteins to self-assemble into geometric shapes on demand. In...

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Last unknown structure of HIV-1 solved, another step in efforts to disarm the...

A University of Alabama at Birmingham team led by Jamil Saad, Ph.D., has solved the last unknown protein structure of HIV-1, the retrovirus that can cause AIDS.

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The birth of a new protein

A yeast protein that evolved from scratch can fold into a three-dimensional shape—contrary to the general understanding of young proteins—according to new research led by the University of Arizona.

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Hacking the bacterial social network

Whenever we use our smartphones to check social media, we face loads of bacteria on the devices—even more than on toilet seats, according to a University of Arizona study. Those bacteria may have their...

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Scientists unveil structure of protein critical for gene expression

The technique of cryo-electron microscopy - for which MRC scientist Dr Richard Henderson won a Nobel Prize earlier this month - has now been used to solve the structure of a protein complex critical...

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Crystals in a pink X-ray beam

A newly developed experimental set-up allows the X-ray structure determination of biomolecules such as proteins with far smaller samples and shorter exposure times than before. At so-called synchrotron...

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Researchers probe brain disease-causing proteins at the atomic level

Researchers studying a protein that causes a hereditary degenerative brain disease in humans have discovered that the human, mouse and hamster forms of the protein, which have nearly identical amino...

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Not so different after all: Human cells, hardy microbes share common ancestor

To Tom Santangelo, single-celled microorganisms called archaea are like ancient mariners, surviving among the most extreme conditions on Earth, including volcanic vents in the deep ocean.

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The isoforms of the HP1 protein regulate the organization and structure of...

Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), led by Dr. Àlex Vaquero, have elucidated the role of HP1 proteins in relation to...

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Solving the mysteries of life: Crystallographers identify 1,000 protein...

The Canadian Light Source is celebrating two milestones reached by scientists who have conducted research at the national facility at the University of Saskatchewan.

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Structure of primary optogenetic tool revealed

An international team of researchers has determined the 3-D structure of channelrhodopsin 2, a membrane protein widely used in optogenetics to control nerve cells with light. Optogenetics is a...

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Cryo-EM reveals 'crown-like' structure of protein responsible for regulating...

A team led by scientists at Van Andel Research Institute (VARI) has revealed for the first time the atomic-level structure of a promising drug target for conditions such as stroke and traumatic brain...

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New method enables automated fast investigation of enzymatic processes

Scientists at DESY have developed a new method that enables automated and fast screening of promising drug candidates. This novel technique, called mix-and-diffuse serial synchrotron crystallography,...

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Researchers reveal fail-safe structure of enzyme linked to Alzheimer's, cancer

Like millions of Americans, Harvard Medical School postdoctoral fellow Tom Seegar struggled as he watched several family members decline from Alzheimer's disease.

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Scientists develop new approach to identify important undiscovered functions...

In the bustling setting of the cell, proteins encounter each other by the thousands. Despite the hubbub, each one manages to selectively interact with just the right partners, thanks to specific...

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Researchers get first complete look at protein behind sense of touch

Scientists at The Scripps Research Institute (TSRI) have solved the mystery of the structure of Piezo1, a member of a family of proteins that convert physical stimuli such as touch or blood flow into...

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Breaking up (protein complexes) is hard to do, but new study shows how

A new study by University of Wisconsin-Madison researchers identified the structural basis for how tightly bound protein complexes are broken apart to become inactivated. The structure explains why the...

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Snapshot of DNA repair

DNA is like the computer code of the body, and it must be preserved for our bodies to survive. Yet, as cells grow and change, DNA is vulnerable to defects, especially double strand breaks (DSBs). In...

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New research could significantly accelerate drug discovery

Many drugs work by inhibiting protein enzymes associated with a particular disease. Unfortunately, the same drugs can inhibit protein enzymes unrelated to the disease, resulting in harmful side...

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Cryo-EM reveals critical protein-modifying complex and potential drug target

Scientists have revealed the atomic-level structure of a molecular complex responsible for modifying proteins, possibly paving the way for the development of new medications for cancer and a host of...

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How single-cell archaea determine what direction to swim

Dr. Tessa Quax has identified the structure of a central protein used by archaea to determine the direction to swim. Archaea are single-cell life forms without a nucleus. She also studied which...

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